Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186894 | 0.87 | SMN1; SMN2 (0.55) | RAB9ANPC1KMT2AHTTLMNA | |
| SCHEMBL6185825 | 0.78 | TYK2 (0.45) | RAB9ANPC1MEN1KMT2AHTT | |
| SCHEMBL6189327 | 0.77 | HPGD (0.46) | MEN1KMT2AHTTLMNAMAPT | |
| SCHEMBL6185706 | 0.76 | MAOB (0.42) | RAB9ANPC1MEN1KMT2AHTT | |
| SCHEMBL6188945 | 0.76 | KMT2A (0.44) | RAB9AMEN1KMT2AHTTLMNA | |
| SCHEMBL6186285 | 0.76 | MAOA (0.49) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL6185686 | 0.75 | DAPK3 (0.48) | RAB9ANPC1L3MBTL1MEN1KMT2A | |
| SCHEMBL6185134 | 0.75 | MAOA (0.54) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6186843 | 0.75 | ALDH1A1 (0.40) | RAB9AKMT2AALDH1A1TSHR | |
| SCHEMBL6187736 | 0.75 | APOBEC3G (0.36) | RAB9ANPC1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |