Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188945 | 0.91 | KMT2A (0.44) | ALDH1A1HPGDHDAC8KDM4ETSHR | |
| SCHEMBL6185825 | 0.89 | TYK2 (0.45) | ALDH1A1HPGDHDAC8KDM4EGAA | |
| SCHEMBL6185686 | 0.81 | DAPK3 (0.48) | ALDH1A1HPGDKDM4EKMT2ARAB9A | |
| SCHEMBL6189327 | 0.80 | HPGD (0.46) | ALDH1A1HPGDKDM4EALOX15GAA | |
| SCHEMBL6185706 | 0.79 | MAOB (0.42) | ALDH1A1HPGDKDM4EPRNPMTNR1A | |
| SCHEMBL6186285 | 0.78 | MAOA (0.49) | ALDH1A1KDM4EGAA | |
| SCHEMBL6185134 | 0.77 | MAOA (0.54) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL6188852 | 0.75 | RAB9A (0.55) | ALDH1A1TSHRKMT2ARAB9A | |
| SCHEMBL6190881 | 0.74 | PARP1 (0.47) | HPGDALOX15KMT2ARAB9A | |
| SCHEMBL6185980 | 0.74 | LMNA (0.41) | ALDH1A1ALOX15GAAKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |