Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NGFR | P08138 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185980 | 0.83 | LMNA (0.41) | NGFRMAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL6186247 | 0.80 | ALDH1A1 (0.67) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8315715 | 0.78 | ALDH1A1 (0.59) | NGFRMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL6185251 | 0.77 | HPGD (0.47) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6187358 | 0.77 | F2R (0.51) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6188924 | 0.75 | LMNA (0.39) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6185359 | 0.75 | MAOA (0.48) | SMN1; SMN2ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL6188736 | 0.75 | MAOA (0.51) | SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL6186086 | 0.74 | MAPT (0.39) | MAPTSMN1; SMN2THRBLMNAMEN1 | |
| SCHEMBL13684477 | 0.73 | ALDH1A1 (0.57) | NGFRMAPTSMN1; SMN2THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |