Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908140 | 0.72 | CA9 (0.52) | SMN1; SMN2GAALMNAALDH1A1MAPT | |
| SCHEMBL1569157 | 0.71 | L3MBTL1 (0.77) | HSD17B10SMN1; SMN2GAAMAPK1LMNA | |
| SCHEMBL5501946 | 0.69 | KDM4E (0.51) | SMN1; SMN2ALDH1A1CYP3A4POLB | |
| SCHEMBL29783179 | 0.69 | RAB9A (0.73) | HSD17B10SMN1; SMN2GAALMNAALDH1A1 | |
| SCHEMBL21065527 | 0.69 | HTT (0.68) | HSD17B10GAAALDH1A1MAPTHTT | |
| SCHEMBL30828595 | 0.67 | MMP13 (0.88) | SMN1; SMN2GAAMAPK1LMNAMMP13 | |
| SCHEMBL1161697 | 0.67 | MMP13 (0.82) | SMN1; SMN2GAAMAPK1LMNAMMP13 | |
| SCHEMBL30437853 | 0.67 | GAA (0.64) | HSD17B10SMN1; SMN2GAAMAPK1LMNA | |
| SCHEMBL334662 | 0.67 | GAA (0.64) | HSD17B10SMN1; SMN2GAAMAPK1LMNA | |
| SCHEMBL10405358 | 0.67 | ALDH1A1 (0.58) | HSD17B10SMN1; SMN2GAAMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | Chiron Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003082272-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |