Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 5/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555261 | 0.90 | SIGMAR1 (0.35) | EPHX1SIGMAR1CHRM5CHRM3OPRD1 | |
| SCHEMBL14655522 | 0.85 | EPHX1 (0.52) | EPHX1DPP4DPP7KCNH2 | |
| SCHEMBL1022186 | 0.85 | CHRNB2 (0.34) | SIGMAR1OPRD1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL1022188 | 0.85 | CHRNB2 (0.34) | SIGMAR1OPRD1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL1554022 | 0.81 | CHRM2 (0.33) | SIGMAR1CHRM3OPRD1CHRNB2CHRNA3 | |
| SCHEMBL1555130 | 0.80 | CYP2D6 (0.37) | EPHX1SIGMAR1OPRD1OPRM1OPRK1 | |
| SCHEMBL1553591 | 0.80 | SIGMAR1 (0.39) | SIGMAR1OPRD1OPRM1OPRK1CHRNB2 | |
| SCHEMBL1554232 | 0.80 | CYP2D6 (0.37) | EPHX1SIGMAR1OPRD1OPRM1OPRK1 | |
| SCHEMBL944062 | 0.79 | EPHX1 (0.46) | EPHX1CA2DPP4DPP7KCNH2 | |
| Hydrochloric Acid SCHEMBL5410658 | 0.79 | CA2 (0.44) | SIGMAR1CHRM5CHRM3OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
| US-4495186-A | SALT FORMATION WITH A DIHYDROXYALUMINUM-A-HYDROXYCARBAXYLIC ACID | CAMILLO CORVI S.P.A. (IT) | 1985-01-22 | — | — | US | disclosed |