Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187979 | 0.75 | APOBEC3G (0.40) | APOBEC3GMAPTHTTMAPK1KMT2A | |
| SCHEMBL6188852 | 0.75 | RAB9A (0.55) | MAPTRAB9AHTTLMNATSHR | |
| SCHEMBL6185825 | 0.75 | TYK2 (0.45) | MAPTRAB9AHTTLMNAKMT2A | |
| SCHEMBL6491956 | 0.75 | AKR1C3 (0.35) | MAPTPTGESJAK2JAK1TYK2 | |
| SCHEMBL6189327 | 0.74 | HPGD (0.46) | MAPTHTTLMNAALOX15KMT2A | |
| SCHEMBL6186285 | 0.72 | MAOA (0.49) | JAK2JAK1ALDH1A1MAOBTYK2 | |
| SCHEMBL6186843 | 0.71 | ALDH1A1 (0.40) | RAB9ATSHRALOX15KMT2AHPGD | |
| SCHEMBL6185134 | 0.71 | MAOA (0.54) | LMNAHPGDJAK2ALDH1A1MAOB | |
| SCHEMBL6185706 | 0.71 | MAOB (0.42) | MAPTRAB9AHTTLMNAMAPK1 | |
| SCHEMBL6188945 | 0.70 | KMT2A (0.44) | RAB9AHTTLMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |