Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190027 | 0.87 | HTR6 (0.48) | HTR6 | |
| SCHEMBL6236033 | 0.84 | HTR6 (0.52) | HTR6 | |
| SCHEMBL4659557 | 0.83 | HTR6 (0.62) | HTR6HTR3EHTR3BADRB1DRD2 | |
| SCHEMBL31587937 | 0.81 | MEN1 (0.59) | HTR6 | |
| SCHEMBL4416491 | 0.79 | HTR6 (0.80) | HTR6 | |
| SCHEMBL8090756 | 0.79 | HTR6 (0.63) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13979786 | 0.79 | HTR6 (0.65) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4550063 | 0.78 | HTR6 (0.49) | HTR6 | |
| SCHEMBL31588485 | 0.78 | HTR6 (0.53) | HTR6 | |
| SCHEMBL4659386 | 0.78 | HTR6 (0.60) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |