Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 12/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190123 | 0.86 | CYP2C9 (0.37) | CYP2C9ELANEHCAR3HCAR2HSD11B1 | |
| SCHEMBL6191091 | 0.82 | KDM4E (0.34) | CYP2C9NR3C2L3MBTL1 | |
| SCHEMBL6192535 | 0.79 | CNR2 (0.36) | NR3C2L3MBTL1 | |
| SCHEMBL6192554 | 0.78 | MMP2 (0.36) | CYP2C9NR3C2ELANE | |
| SCHEMBL6175172 | 0.75 | LDHA (0.38) | CYP2C9NR3C2ELANEHSD11B1 | |
| SCHEMBL6174556 | 0.72 | OPRD1 (0.44) | CYP2C9NR3C2 | |
| SCHEMBL6189771 | 0.72 | MLNR (0.34) | CYP2C9NR3C2ELANEL3MBTL1HSD11B1 | |
| SCHEMBL6190741 | 0.70 | ACP3 (0.33) | NR3C2ELANEL3MBTL1HSD11B1 | |
| SCHEMBL6189549 | 0.68 | MMP2 (0.34) | CYP2C9ELANE | |
| SCHEMBL6174650 | 0.68 | OPRD1 (0.44) | CYP2C9NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | claimed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |