SCHEMBL6192255

SCHEMBL6192255

COc1cccc(C(=O)CN2CCC(Cn3c(=N)sc4cc(Cl)ccc43)CC2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CBX7 O95931 2/20 0.46
CDYL2 Q8N8U2 2/20 0.46
CDYL Q9Y232 2/20 0.46
CDY1; CDY1B Q9Y6F8 2/20 0.46
MAPT P10636 3/20 0.43
DRD4 P21917 3/20 0.43
ALDH1A1 P00352 3/20 0.43
DRD2 P14416 1/20 0.43
KDM4E B2RXH2 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HPGD P15428 2/20 0.43
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
KDM2B Q8NHM5 2/20 0.42
CNR2 P34972 1/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6192972 0.91 MEN1 (0.48) MEN1KMT2AALDH1A1KDM4ETP53
SCHEMBL6189119 0.88 ALDH1A1 (0.40) ALDH1A1
SCHEMBL8124528 0.87 HTR7 (0.42) MEN1KMT2AALDH1A1DRD2MGLL
SCHEMBL6192891 0.84 CXCR3 (0.43) MEN1KMT2AMAPTDRD4ALDH1A1
SCHEMBL6191286 0.83 CCR2 (0.38) MEN1KMT2AMAPTALDH1A1DRD2
SCHEMBL6189192 0.81 CNR1 (0.40) MEN1KMT2AALDH1A1CNR2GAA
Hydrochloric Acid SCHEMBL6188611 0.81 HTR2A (0.43) MAPTALDH1A1DRD2KDM4ESMN1; SMN2
Hydrochloric Acid SCHEMBL6189117 0.81 GRIN2B (0.41) MAPTALDH1A1KDM4ESMN1; SMN2GAA
Hydrochloric Acid SCHEMBL6189120 0.81 GRIN2B (0.41) MAPTALDH1A1KDM4ESMN1; SMN2GAA
Hydrochloric Acid SCHEMBL6189111 0.81 GRIN2B (0.41) MAPTALDH1A1KDM4ESMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1043319-B1 NOVEL ALKYLAMINO DERIVATIVES MITSUBISHI CHEM CORP (JP) 2005-03-16 EP disclosed
EP-1043319-A1 NOVEL ALKYLAMINO DERIVATIVES MITSUBISHI CHEMICAL CORPORATION (JP) 2000-10-11 EP disclosed