Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.49 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200573 | 0.85 | HTR6 (0.57) | HTR6BAZ2BMAPTLMNATRPV1 | |
| SCHEMBL7614729 | 0.85 | HTR6 (0.43) | HTR6BAZ2BSFRP1PIK3CAMAPT | |
| SCHEMBL7614732 | 0.85 | HTR6 (0.43) | HTR6BAZ2BSFRP1PIK3CAMAPT | |
| SCHEMBL7614726 | 0.85 | HTR6 (0.43) | HTR6BAZ2BSFRP1PIK3CAMAPT | |
| SCHEMBL6038224 | 0.83 | HTR6 (0.54) | HTR6BAZ2BMAPTLMNATRPV1 | |
| SCHEMBL6474214 | 0.82 | LMNA (0.60) | BAZ2BMAPTLMNATRPV1 | |
| SCHEMBL6038429 | 0.81 | HTR6 (0.67) | HTR6BAZ2BMAPT | |
| SCHEMBL6474229 | 0.80 | BAZ2B (0.63) | BAZ2BMAPTLMNAPABPC1ATM | |
| SCHEMBL5373313 | 0.80 | BAZ2B (0.63) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL5362823 | 0.79 | BAZ2B (0.66) | BAZ2BMAPTPOLBLMNAPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351961-B1 | SUBSTITUTED INDOLINES AS 5-HT RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2005-07-27 | — | — | EP | disclosed |
| US-20020160999-A1 | Substituted indolines | PHARMACIA & UPJOHN COMPANY | 2002-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160999-A1 | Substituted indolines | TPH1, TPH2, NLN | HTR6 16/4885BAZ2B 3542/4885SFRP1 4249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.