Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195293 | 0.84 | KDM4E (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6197640 | 0.82 | KDM4E (0.46) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6196888 | 0.80 | HTT (0.48) | HTTSMN1; SMN2 | |
| SCHEMBL8850201 | 0.80 | FABP4 (0.40) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6197604 | 0.79 | MAPK1 (0.48) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6198182 | 0.79 | KMT2A (0.42) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6197536 | 0.79 | CYP2D6 (0.38) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6193484 | 0.78 | KDM4E (0.47) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL27481986 | 0.77 | KMT2A (0.41) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL6199137 | 0.76 | KDM4E (0.40) | KDM4ETP53CYP2D6HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |