Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.86 |
| ▸ | MAOB | P27338 | 6/20 | 0.75 |
| ▸ | BCHE | P06276 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.75 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.75 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.75 |
| ▸ | MAOA | P21397 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.71 |
| ▸ | RELA | Q04206 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76030 | 1.00 | MAPT (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL5753797 | 1.00 | MAPT (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL27977352 | 0.95 | MAPT (0.90) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL23789072 | 0.93 | MAPT (0.87) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL7193506 | 0.93 | CYP1B1 (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL77498 | 0.93 | CYP1B1 (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL12533800 | 0.91 | MAPT (0.82) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| 4,4'-Dimethylchalcone SCHEMBL979560 | 0.90 | MAPT (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| 4,4'-Dimethylchalcone SCHEMBL979559 | 0.90 | MAPT (1.00) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 | |
| SCHEMBL9915665 | 0.90 | CYP1B1 (0.91) | MAPTCYP3A4ALDH1A1HPGDCYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
| US-4261988-A | ANTICHOLESTEROL AGENTS USED IN ANIMAL HUSBANDRY | BAYER AKTIENGESELLSCHAFT (DE) | 1981-04-14 | — | — | US | disclosed |