Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27579381 | 0.87 | LTA4H (0.59) | MAPK14LTA4HTEAD1L3MBTL1ALDH1A1 | |
| SCHEMBL9798371 | 0.87 | LTA4H (0.54) | LTA4HTEAD1L3MBTL1ALDH1A1POLB | |
| SCHEMBL9546526 | 0.85 | L3MBTL1 (0.55) | MAPK14LTA4HTEAD1L3MBTL1ALDH1A1 | |
| SCHEMBL14527443 | 0.81 | TLR7 (0.57) | BRAFKDRMAPK14TNNI3KL3MBTL1 | |
| SCHEMBL694092 | 0.79 | LTA4H (0.49) | LTA4HTEAD1L3MBTL1ALDH1A1POLB | |
| SCHEMBL15635197 | 0.79 | PPARG (0.55) | MAPK14LTA4HTEAD1L3MBTL1ALDH1A1 | |
| SCHEMBL476378 | 0.79 | ALDH1A1 (0.66) | LTA4HL3MBTL1ALDH1A1NPSR1MAPT | |
| SCHEMBL13809396 | 0.79 | LTA4H (0.52) | MAPK14LTA4HTEAD1L3MBTL1ALDH1A1 | |
| SCHEMBL4043144 | 0.79 | LTA4H (0.53) | BRAFKDRMAPK14TNNI3KLTA4H | |
| SCHEMBL5542591 | 0.79 | LTA4H (0.52) | MAPK14LTA4HTEAD1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208104-B1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES | AGOURON PHARMA (US) | 2005-01-19 | — | — | EP | disclosed |
| US-4411904-A | Diphenylpropanamines, compositions thereof and use thereof | WARNER-LAMBERT COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4364954-A | NEUROLEPTIC AGENT | WARNER-LAMBERT COMPANY (US) | 1982-12-21 | — | — | US | disclosed |
| US-4292321-A | 1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof | WARNER-LAMBERT COMPANY (US) | 1981-09-29 | — | — | US | disclosed |
| US-4218456-A | 1-(4-Fluorophenyl)-4-(1,2,3,6-tetrahydro-4-phenoxy-1-pyridinyl)-butanones | WARNER-LAMBERT COMPANY (US) | 1980-08-19 | — | — | US | disclosed |