SCHEMBL620156

SCHEMBL620156

CNS(=O)(=O)c1ccc(Br)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.64
GAA P10253 2/20 0.64
CA2 P00918 4/20 0.61
CA1 P00915 3/20 0.61
CA12 O43570 3/20 0.61
CA9 Q16790 3/20 0.61
CA14 Q9ULX7 3/20 0.61
CA3 P07451 2/20 0.61
CA4 P22748 2/20 0.61
CA6 P23280 2/20 0.61
CA5A P35218 2/20 0.61
CA7 P43166 2/20 0.61
CA13 Q8N1Q1 2/20 0.61
CA5B Q9Y2D0 2/20 0.61
MMP2 P08253 2/20 0.61
MMP1 P03956 1/20 0.61
MMP9 P14780 1/20 0.61
MMP8 P22894 1/20 0.61
MMP13 P45452 1/20 0.61
HTT P42858 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11511980 0.98 SMN1; SMN2 (0.61) SMN1; SMN2GAACA2CA1CA12
SCHEMBL6609278 0.94 SMN1; SMN2 (0.57) SMN1; SMN2GAACA2CA1CA12
SCHEMBL7629070 0.87 SMN1; SMN2 (0.80) SMN1; SMN2GAACA2CA1CA12
SCHEMBL10005288 0.80 MMP2 (0.67) GAACA2CA1CA12CA9
SCHEMBL8080277 0.80 SMN1; SMN2 (0.70) SMN1; SMN2GAACA2CA1CA12
SCHEMBL3884026 0.80 L3MBTL1 (0.68) SMN1; SMN2GAACA2CA1CA12
SCHEMBL30960 0.78 GAA (1.00) SMN1; SMN2GAACA2CA1CA12
SCHEMBL1804982 0.78 SMN1; SMN2 (0.67) SMN1; SMN2GAACA2CA1CA12
SCHEMBL14347243 0.78 CA2 (0.64) GAACA2CA1CA12CA9
SCHEMBL709242 0.76 SMN1; SMN2 (0.64) SMN1; SMN2GAACA2CA1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 389 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-4743453-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION Pretzel Therapeutics, Inc. (US) 2026-05-20 EP disclosed
CN-120117949-A Method for directly preparing tertiary amine compound from aromatic aldehyde, ketone and secondary amine 湖南大学 2025-06-10 CN disclosed
US-12264158-B2 Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death HEPAREGENIX GMBH (DE) 2025-04-01 US disclosed
WO-2025015178-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION PRETZEL THERAPEUTICS, INC. (US) 2025-01-16 WO disclosed
CN-118619855-A Amide or ester compound or derivative thereof and application thereof 暨南大学 2024-09-10 CN disclosed
EP-3746437-B1 PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH HEPAREGENIX GMBH (DE) 2024-08-21 EP disclosed
CN-118271212-A Caryophyllane derivative, preparation method, application and pharmaceutical composition 赣江中药创新中心 2024-07-02 CN disclosed
US-20240116931-A1 PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH HEPAREGENIX GMBH (DE) 2024-04-11 US disclosed
EP-0597540-A1 Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents STERLING WINTHROP INC. (US) 1994-05-18 EP disclosed
EP-0533266-A1 Benzanilide derivatives as 5-HT1D antagonists GLAXO GROUP LIMITED (GB) 1993-03-24 EP disclosed
CN-1016963-B HERBICIDE COMPOSITION CONTG. BENZENE SULFONAMIDE AS ACTIVE INGREDIENT MITSUBISHI CHEM IND (JP) 1992-06-10 CN disclosed
EP-0326170-B1 SULFONAMIDE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT MITSUBISHI KASEI CORPORATION (JP) 1991-12-11 EP disclosed
US-5043142-A Measuring peroxide-active substances TERUMO KABUSHIKI KAISHA (JP) 1991-08-27 US disclosed
US-4971620-A APPLYING TO FIELDS TO KILL WEEDS MITSUBISHI KASEI CORPORATION (JP) 1990-11-20 US disclosed
CN-1036564-A Sulfanilamide (SN) and contain the weedkiller of sulfanilamide (SN) as activeconstituents MITSUBISHI CHEM IND (JP) 1989-10-25 CN disclosed
EP-0328643-A1 (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION TERUMO KABUSHIKI KAISHA (JP) 1989-08-23 EP disclosed
EP-0326170-A1 Sulfonamide and herbicide containing the same as active ingredient MITSUBISHI KASEI CORPORATION (JP) 1989-08-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116931-A1 PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH MAPK4, MAP3K4, MAP4K1 SMN1; SMN2 2354/4885GAA 4535/4885CA2 4640/4885
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST SMN1; SMN2 4603/4885GAA 218/4885CA2 3102/4885
US-12264158-B2 Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death MAPK4, MAP3K4, MAP4K1 SMN1; SMN2 2354/4885GAA 4535/4885CA2 4640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.