Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499649 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A | |
| Hydrochloric Acid SCHEMBL9502312 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A | |
| SCHEMBL9500292 | 0.83 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A | |
| SCHEMBL1431310 | 0.83 | ACHE (0.61) | SMN1; SMN2LMNAHTTHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9501501 | 0.83 | HSD11B1 (0.67) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A | |
| Hydrochloric Acid SCHEMBL9501099 | 0.82 | LMNA (0.68) | SMN1; SMN2LMNAHTTHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL10339587 | 0.82 | ACHE (0.60) | SMN1; SMN2LMNAHTTHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9095770 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A | |
| SCHEMBL6202951 | 0.81 | LMNA (0.68) | SMN1; SMN2ALDH1A1LMNAHTTHSD11B1 | |
| SCHEMBL14636954 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1LMNAHTTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
| EP-0325268-B1 | 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |