Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10058270 | 0.83 | GAA (0.37) | GAATAAR1DPP4CES2CES1 | |
| SCHEMBL6201831 | 0.78 | DPP4 (0.35) | GAATAAR1DPP4CES2CES1 | |
| SCHEMBL6204256 | 0.78 | TAAR1 (0.41) | THRBTAAR1DPP4CYP2D6KCNH2 | |
| SCHEMBL6204700 | 0.73 | CES2 (0.37) | GAATAAR1DPP4CES2CES1 | |
| SCHEMBL10025488 | 0.72 | GAA (0.38) | GAATAAR1DPP4CES2CES1 | |
| SCHEMBL2422907 | 0.72 | GAA (0.38) | GAATAAR1DPP4CES2CES1 | |
| SCHEMBL16054697 | 0.72 | GAA (0.51) | GAATAAR1BACE1KDM4EKCNH2 | |
| SCHEMBL8696467 | 0.72 | ITGB2 (0.45) | TAAR1DPP4CES2CES1BACE1 | |
| SCHEMBL28410212 | 0.71 | CES2 (0.42) | CES2CES1CYP2D6KCNH2 | |
| SCHEMBL23102238 | 0.69 | LMNA (0.49) | KDM4ECYP2D6KCNH2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |