Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204698 | 0.82 | CES2 (0.38) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL10058270 | 0.81 | GAA (0.37) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL10025488 | 0.78 | GAA (0.38) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL2422907 | 0.74 | GAA (0.38) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL6201835 | 0.73 | THRB (0.36) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL16054697 | 0.69 | GAA (0.51) | GAATAAR1BACE1KDM4EALDH1A1 | |
| SCHEMBL6203911 | 0.69 | SMN1; SMN2 (0.36) | CES2CES1GAATAAR1DPP4 | |
| SCHEMBL113326 | 0.69 | TAAR1 (0.48) | CES2CES1GAATAAR1BACE1 | |
| SCHEMBL170907 | 0.69 | GABRA1 (0.43) | GAATAAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6201831 | 0.68 | DPP4 (0.35) | CES2CES1GAATAAR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |