Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343011 | 0.90 | MAPT (0.77) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL17703534 | 0.84 | NPSR1 (0.82) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6203117 | 0.84 | MAPT (0.69) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7877273 | 0.81 | NPSR1 (0.77) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8066458 | 0.81 | ALDH1A1 (0.59) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7877389 | 0.81 | RAB9A (0.68) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL14662793 | 0.80 | MEN1 (0.63) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28541413 | 0.80 | ALDH1A1 (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL27972914 | 0.79 | NPSR1 (0.74) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28219066 | 0.78 | ALDH1A1 (0.73) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734519-B1 | ANTI-BIOFILM COMPOUNDS | UNIV LOUISVILLE RES FOUND (US) | 2016-05-04 | — | — | EP | disclosed |
| EP-2734519-B1 | ANTI-BIOFILM COMPOUNDS | UNIV LOUISVILLE RES FOUND (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9167820-B2 | Anti-biofilm compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION INC. (US) | 2014-06-12 | — | — | US | disclosed |
| EP-2734519-A1 | ANTI-BIOFILM COMPOUNDS | University Of Louisville Research Foundation, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013016206-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| WO-2013016206-A1 | ANTI-BIOFILM COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140161845-A1 | ANTI-BIOFILM COMPOUNDS | MSR1, NPR1, FPR1 | MAPT 4865/4885NPC1 354/4885RAB9A 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.