Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.75 |
| ▸ | MAPT | P10636 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | HTT | P42858 | 3/20 | 0.75 |
| ▸ | ATM | Q13315 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713764 | 0.84 | MAPT (0.77) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL9198947 | 0.83 | MAPT (0.75) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL7719197 | 0.81 | ALDH1A1 (0.71) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL9035306 | 0.78 | DPP4 (0.47) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL10584214 | 0.78 | ALDH1A1 (0.97) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL6320116 | 0.77 | SMN1; SMN2 (0.81) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL27896467 | 0.77 | MAPT (0.73) | ALDH1A1MAPTLMNAHTTATM | |
| Hydrochloric Acid SCHEMBL10829995 | 0.77 | POLB (0.57) | ALDH1A1MAPTLMNAHTTATM | |
| SCHEMBL6201853 | 0.77 | MDM2 (0.70) | MAPTHTTATMRAB9ANPC1 | |
| SCHEMBL13892504 | 0.76 | SMN1; SMN2 (0.49) | ALDH1A1MAPTLMNAHTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |