Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238748 | 0.88 | ALDH1A1 (0.56) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL5471056 | 0.85 | MAPT (0.65) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL546450 | 0.84 | ALDH1A1 (0.64) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL30061320 | 0.84 | ALDH1A1 (0.64) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL26234109 | 0.81 | MAPT (0.64) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL16054038 | 0.81 | ALDH1A1 (0.59) | MAPTPOLBPKMLMNAALDH1A1 | |
| SCHEMBL6609950 | 0.80 | MAPT (0.56) | MAPTPOLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL11367032 | 0.79 | ATM (0.48) | MAPTPKMLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24290490 | 0.78 | NCF1 (0.48) | MAPTALDH1A1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL21600747 | 0.78 | ALDH1A1 (0.63) | MAPTPOLBLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | Amgen Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003101985-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC. (US) | 2003-12-11 | — | — | WO | disclosed |