Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | CTSG | P08311 | 2/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.48 |
| ▸ | CMA1 | P23946 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26263205 | 0.84 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAKMT2AHSP90AA1 | |
| SCHEMBL19707284 | 0.81 | MEN1 (0.47) | ALDH1A1SMN1; SMN2LMNAKMT2ARAB9A | |
| SCHEMBL2853466 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNARAB9APRSS1CTSG | |
| SCHEMBL265506 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNARAB9APRSS1CTSG | |
| SCHEMBL1427713 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNARAB9APRSS1CTSG | |
| SCHEMBL4332252 | 0.79 | LMNA (0.47) | ALDH1A1SMN1; SMN2LMNAKMT2ARAB9A | |
| SCHEMBL24241537 | 0.79 | TAS1R3 (0.53) | ALDH1A1LMNAKMT2AHSP90AA1RAB9A | |
| SCHEMBL16234873 | 0.78 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2LMNAKMT2AHSP90AA1 | |
| SCHEMBL16234870 | 0.78 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2LMNAKMT2AHSP90AA1 | |
| SCHEMBL8550795 | 0.77 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAKMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |