Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203291 | 0.90 | EGFR (0.39) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL6205452 | 0.83 | EGFR (0.36) | SMN1; SMN2MPOGSK3BMEN1KMT2A | |
| SCHEMBL6204330 | 0.82 | CNR1 (0.39) | FLT1SMN1; SMN2L3MBTL1GSK3BMEN1 | |
| SCHEMBL6202957 | 0.82 | ALDH1A1 (0.35) | SMN1; SMN2L3MBTL1GSK3BMEN1KMT2A | |
| SCHEMBL6203101 | 0.82 | NPC1 (0.38) | SMN1; SMN2L3MBTL1GSK3BMEN1KMT2A | |
| SCHEMBL6205611 | 0.82 | MEN1 (0.38) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL6205378 | 0.80 | KMT2A (0.40) | SMN1; SMN2GSK3BMEN1KMT2ALMNA | |
| SCHEMBL6204133 | 0.80 | FPR1 (0.43) | MEN1KMT2ALMNA | |
| SCHEMBL6202823 | 0.80 | EGFR (0.42) | SMN1; SMN2L3MBTL1GSK3BMEN1KMT2A | |
| SCHEMBL6204891 | 0.80 | MAPT (0.38) | FLT1SMN1; SMN2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |