Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204133 | 0.92 | FPR1 (0.43) | EGFRSRCFGFR4HIF1AMAPK1 | |
| SCHEMBL6203291 | 0.86 | EGFR (0.39) | EGFRSRCMAPTMAPK1MEN1 | |
| SCHEMBL6206042 | 0.85 | CYP3A4 (0.43) | MAPTMEN1KMT2APDE4BL3MBTL1 | |
| SCHEMBL6204913 | 0.85 | EGFR (0.42) | EGFRSRCHIF1AMAPTALOX12 | |
| SCHEMBL6203101 | 0.84 | NPC1 (0.38) | EGFRSRCMAPTMAPK1MEN1 | |
| SCHEMBL6202957 | 0.84 | ALDH1A1 (0.35) | EGFRSRCMAPTMAPK1GAA | |
| SCHEMBL6204330 | 0.81 | CNR1 (0.39) | EGFRSRCMAPTMAPK1MEN1 | |
| SCHEMBL6205378 | 0.80 | KMT2A (0.40) | EGFRSRCMAPTALOX12MAPK1 | |
| SCHEMBL6202905 | 0.80 | LTA4H (0.41) | MAPTMEN1KMT2AGSK3BL3MBTL1 | |
| SCHEMBL6205452 | 0.80 | EGFR (0.36) | EGFRSRCMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |