Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205452 | 0.91 | EGFR (0.36) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6204330 | 0.91 | CNR1 (0.39) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6203291 | 0.89 | EGFR (0.39) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6205378 | 0.87 | KMT2A (0.40) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6204202 | 0.84 | CXCR2 (0.36) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6203101 | 0.84 | NPC1 (0.38) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6202823 | 0.84 | EGFR (0.42) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6202905 | 0.82 | LTA4H (0.41) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6204448 | 0.82 | MAPT (0.34) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL6204891 | 0.81 | MAPT (0.38) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |