Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204330 | 0.89 | CNR1 (0.39) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6203291 | 0.87 | EGFR (0.39) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6205452 | 0.87 | EGFR (0.36) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6202957 | 0.87 | ALDH1A1 (0.35) | KMT2AMEN1TDP1BLMRECQL | |
| SCHEMBL6204202 | 0.85 | CXCR2 (0.36) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6203101 | 0.84 | NPC1 (0.38) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6204448 | 0.83 | MAPT (0.34) | KMT2AMEN1TDP1BLMMAPK1 | |
| SCHEMBL6206042 | 0.82 | CYP3A4 (0.43) | KMT2AMEN1TDP1ALDH1A1LMNA | |
| SCHEMBL6204891 | 0.82 | MAPT (0.38) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL6202905 | 0.80 | LTA4H (0.41) | KMT2AMEN1GSK3BLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |