Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526090 | 0.85 | NPC1 (0.48) | PNMTIDO1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL14720120 | 0.80 | PNMT (0.41) | PNMTTAAR1IDO1MEN1KMT2A | |
| SCHEMBL28876911 | 0.80 | PPARG (0.51) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15783026 | 0.79 | NR3C1 (0.45) | IDO1SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL8984622 | 0.79 | PNMT (0.54) | PNMTTAAR1IDO1MEN1KMT2A | |
| SCHEMBL5067377 | 0.77 | PNMT (0.48) | PNMTTAAR1IDO1TAS1R3TAS1R1 | |
| SCHEMBL18567935 | 0.77 | PNMT (0.52) | PNMTTAAR1IDO1SLC6A2SLC6A4 | |
| SCHEMBL5805934 | 0.77 | PNMT (0.52) | PNMTTAAR1IDO1SLC6A2SLC6A4 | |
| SCHEMBL5018770 | 0.76 | PNMT (0.56) | PNMTTAAR1IDO1SLC6A2SLC6A4 | |
| SCHEMBL17653888 | 0.75 | NOS3 (0.50) | PNMTTAAR1IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758647-B1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 2000-11-02 | — | — | EP | disclosed |
| US-5719181-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0758647-A1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | disclosed |