Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21669262 | 0.82 | CYP3A4 (0.45) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL11397144 | 0.78 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3ALDH1A1LMNA | |
| SCHEMBL22964356 | 0.77 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3ALDH1A1LMNA | |
| SCHEMBL11390760 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3ALDH1A1LMNA | |
| SCHEMBL22964351 | 0.77 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3ALDH1A1LMNA | |
| SCHEMBL9979794 | 0.77 | AOC3 (0.34) | CYP3A4 | |
| SCHEMBL18649655 | 0.76 | UGT2B7 (0.48) | CYP2D6LMNA | |
| SCHEMBL1154655 | 0.76 | ALDH1A1 (0.49) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 | |
| SCHEMBL6205149 | 0.76 | ADRB2 (0.44) | SLC6A4LMNASMN1; SMN2IDO1TDO2 | |
| SCHEMBL6099521 | 0.76 | ALDH1A1 (0.49) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |