Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082371 | 1.00 | ATM (0.52) | ATMALDH1A1SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL27396631 | 0.98 | ATM (0.50) | ATMALDH1A1SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL4184360 | 0.81 | ALDH1A1 (0.38) | ATMALDH1A1SMN1; SMN2GAATDP1 | |
| SCHEMBL3582413 | 0.79 | L3MBTL1 (0.55) | ALDH1A1SMN1; SMN2L3MBTL1GAAMEN1 | |
| SCHEMBL30455653 | 0.79 | CA2 (0.45) | GAAKMT2A | |
| SCHEMBL3949996 | 0.79 | CYP1A2 (0.48) | SMN1; SMN2L3MBTL1TDP1KMT2AHTT | |
| SCHEMBL8185942 | 0.79 | CYP1A2 (0.48) | ALDH1A1SMN1; SMN2GAATDP1MEN1 | |
| SCHEMBL2184936 | 0.78 | ATM (0.50) | ATMALDH1A1SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL5517609 | 0.78 | ATM (0.50) | ATMALDH1A1SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL27978837 | 0.78 | ATM (0.50) | ATMALDH1A1SMN1; SMN2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | claimed |