Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203784 | 0.84 | TDP1 (0.39) | KMT2AMEN1 | |
| SCHEMBL1076640 | 0.76 | KMT2A (0.49) | KMT2AMEN1POLBSMN1; SMN2GLA | |
| SCHEMBL1076948 | 0.72 | HCRTR1 (0.44) | HCRTR2 | |
| SCHEMBL1040151 | 0.71 | HCRTR2 (0.72) | HCRTR2TP53TRPM8 | |
| SCHEMBL28194605 | 0.70 | POLB (0.57) | KMT2AKDM4EMEN1POLBSMN1; SMN2 | |
| SCHEMBL18939315 | 0.67 | GAA (0.61) | KMT2AKDM4EMEN1POLBSMN1; SMN2 | |
| SCHEMBL12484617 | 0.67 | PTGER1 (0.54) | KMT2AMEN1TP53 | |
| SCHEMBL1078296 | 0.67 | PTGER1 (0.44) | KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL1076164 | 0.66 | ALDH1A1 (0.54) | HCRTR2KMT2A | |
| SCHEMBL6199052 | 0.65 | HIF1A (0.42) | KMT2AMEN1SMN1; SMN2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-A2 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |