Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GPR6 | P46095 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203700 | 0.84 | KDM4E (0.45) | ALDH1A1SMN1; SMN2CDK2AP1CHEK1TSHR | |
| SCHEMBL7241178 | 0.83 | CHRNB2 (0.48) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4TSHR | |
| SCHEMBL6204321 | 0.82 | HDAC1 (0.48) | HDAC1HDAC6 | |
| SCHEMBL6203532 | 0.82 | HDAC1 (0.48) | HDAC1HDAC6 | |
| SCHEMBL6203499 | 0.82 | HDAC1 (0.48) | HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL15648258 | 0.82 | CHRNB2 (0.47) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4TSHR | |
| SCHEMBL14490487 | 0.80 | HTT (0.53) | ALDH1A1HTTGPR6HDAC1HDAC6 | |
| SCHEMBL29542503 | 0.80 | DYRK1B (0.56) | — | |
| SCHEMBL6204397 | 0.79 | SMYD3 (0.46) | — | |
| SCHEMBL6204513 | 0.79 | SMYD3 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |