Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 7/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204397 | 1.00 | SMYD3 (0.46) | SMYD3ACKR3ATMHCAR2ULK1 | |
| SCHEMBL6204294 | 0.79 | ALDH1A1 (0.51) | — | |
| SCHEMBL6204321 | 0.79 | HDAC1 (0.48) | WNT1GSK3BDYRK1A | |
| SCHEMBL6203499 | 0.79 | HDAC1 (0.48) | WNT1GSK3BDYRK1A | |
| SCHEMBL6203532 | 0.79 | HDAC1 (0.48) | WNT1GSK3BDYRK1A | |
| SCHEMBL6203700 | 0.78 | KDM4E (0.45) | ATMULK1 | |
| SCHEMBL6277414 | 0.77 | SMYD3 (0.47) | SMYD3ACKR3ATMHCAR2ULK1 | |
| SCHEMBL6371533 | 0.73 | HDAC1 (0.50) | ACKR3 | |
| SCHEMBL3879671 | 0.73 | NPC1 (0.47) | ATM | |
| SCHEMBL3877272 | 0.72 | TAS1R3 (0.45) | ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |