Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204601 | 0.81 | PKM (0.41) | LDHASLC6A4CYP1A2IDO1CA1 | |
| SCHEMBL1070963 | 0.80 | SLC6A4 (0.63) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11538137 | 0.79 | SLC6A4 (0.57) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6205901 | 0.79 | TRPA1 (0.46) | IDO1CA12CA7CA9CA14 | |
| SCHEMBL1357677 | 0.78 | TAAR1 (0.46) | SLC6A4CYP1A2CYP2D6TAAR1PPARG | |
| SCHEMBL6204551 | 0.77 | TAAR1 (0.64) | IDO1CMA1AGXTTAAR1SMN1; SMN2 | |
| SCHEMBL15514667 | 0.77 | LTA4H (0.53) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8933391 | 0.77 | SLC6A4 (0.64) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29018022 | 0.77 | LDHA (0.60) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10897973 | 0.76 | SLC6A4 (0.53) | LDHASLC6A4CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |