Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.38 |
| ▸ | RAB9A | P51151 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16211043 | 0.78 | KIF11 (0.40) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL17361823 | 0.78 | ALDH1A1 (0.39) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL182882 | 0.78 | SMN1; SMN2 (0.58) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL10843775 | 0.75 | CYP1A2 (0.56) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL10843574 | 0.75 | ALDH1A1 (0.59) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL31024004 | 0.75 | ALDH1A1 (0.59) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL20939584 | 0.74 | DYRK1A (0.47) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL28939591 | 0.72 | ALDH1A1 (0.34) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7007389 | 0.72 | ALOX5 (0.33) | MAPT | |
| SCHEMBL5528669 | 0.72 | RAB9A (0.55) | MAPTRAB9ASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534681-A1 | SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004002960-A1 | SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-01-08 | — | — | WO | disclosed |