Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160094 | 0.73 | TLR9 (0.36) | SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL29904548 | 0.68 | CHRNB2 (0.51) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL20438926 | 0.68 | CHRNB2 (0.51) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL1822160 | 0.68 | CHRNB2 (0.51) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL29051178 | 0.67 | CHRNB2 (0.50) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL4301470 | 0.66 | MAPT (0.34) | SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL19995723 | 0.66 | CHRNB2 (0.51) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL27913713 | 0.66 | CHRNB2 (0.51) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL4977286 | 0.64 | HTR6 (0.38) | MPOSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL4750469 | 0.64 | CA1 (0.40) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |