Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365391 | 0.74 | PER2 (0.46) | PER2CRY2 | |
| SCHEMBL10416543 | 0.70 | PER2 (0.42) | PER2CRY2 | |
| SCHEMBL24822290 | 0.70 | PER2 (0.39) | PER2CRY2 | |
| SCHEMBL20912198 | 0.70 | KDM4E (0.39) | PER2DRD2DRD3KCNH2BCHE | |
| SCHEMBL9126352 | 0.69 | KDM4E (0.41) | DRD2DRD3KCNH2 | |
| SCHEMBL9632685 | 0.69 | SIGMAR1 (0.32) | SIGMAR1 | |
| SCHEMBL8854156 | 0.68 | PER2 (0.41) | PER2CRY2 | |
| SCHEMBL27797024 | 0.68 | CYP3A4 (0.38) | PER2CRY2 | |
| SCHEMBL4601321 | 0.67 | ALOX5 (0.44) | PER2BCHEACHE | |
| SCHEMBL11934366 | 0.67 | PER2 (0.42) | PER2CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-B1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |