Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913800 | 0.93 | TTR (0.45) | TTRSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL16952669 | 0.88 | TTR (0.47) | TTRSMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL6206074 | 0.85 | LOXL2 (0.42) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5913357 | 0.85 | HTT (0.42) | TTRSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL5913083 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL1667910 | 0.80 | TTR (0.68) | TTRSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL16954759 | 0.79 | TTR (0.50) | TTRSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL9940031 | 0.78 | CA1 (0.43) | ALDH1A1MAPTHTTLMNAGAA | |
| SCHEMBL30062398 | 0.78 | HSPB1 (0.56) | TTRSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL397137 | 0.78 | HSPB1 (0.56) | TTRSMN1; SMN2ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |
| CN-1738798-A | Indole derivatives as somatostatin agonists or antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |