Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204133 | 0.85 | FPR1 (0.43) | EGFRSRCHSD17B10GAAAKR1C3 | |
| SCHEMBL6202823 | 0.85 | EGFR (0.42) | EGFRSRCGSK3BMAPTALDH1A1 | |
| SCHEMBL6206042 | 0.83 | CYP3A4 (0.43) | MAPTALDH1A1CA2 | |
| SCHEMBL6205665 | 0.78 | EGFR (0.36) | EGFRSRCMAPTALDH1A1KDM4C | |
| SCHEMBL6203101 | 0.77 | NPC1 (0.38) | EGFRSRCGSK3BPRKACARPS6KB1 | |
| SCHEMBL6204448 | 0.75 | MAPT (0.34) | EGFRSRCGSK3BMAPTALDH1A1 | |
| SCHEMBL6204202 | 0.75 | CXCR2 (0.36) | EGFRSRCGSK3BMAPTALDH1A1 | |
| SCHEMBL6204330 | 0.75 | CNR1 (0.39) | EGFRSRCGSK3BRPS6KB1MAPT | |
| SCHEMBL6205611 | 0.74 | MEN1 (0.38) | EGFRSRCMAPTALDH1A1HSD17B10 | |
| SCHEMBL6205378 | 0.73 | KMT2A (0.40) | EGFRSRCGSK3BPRKACARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |