Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204133 | 0.86 | FPR1 (0.43) | CYP3A4CYP2C9TSHRCYP2C19KMT2A | |
| SCHEMBL6202823 | 0.85 | EGFR (0.42) | CYP3A4KMT2AMEN1PDE4BLMNA | |
| SCHEMBL6203101 | 0.84 | NPC1 (0.38) | CYP3A4KMT2AMEN1ADORA2ALMNA | |
| SCHEMBL6204913 | 0.83 | EGFR (0.42) | CA2MAPTALDH1A1 | |
| SCHEMBL6205378 | 0.82 | KMT2A (0.40) | CYP3A4TSHRKMT2AMEN1LMNA | |
| SCHEMBL6204330 | 0.82 | CNR1 (0.39) | CYP3A4KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL6205452 | 0.80 | EGFR (0.36) | CYP3A4KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL6204891 | 0.79 | MAPT (0.38) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6202905 | 0.78 | LTA4H (0.41) | KMT2AMEN1LMNASMN1; SMN2MAPT | |
| SCHEMBL6205611 | 0.77 | MEN1 (0.38) | CYP3A4CYP2C9CYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |