SCHEMBL6205086

SCHEMBL6205086

O=C(NCc1ccco1)c1c[nH]c2ccccc2c1=O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.69
ADORA2A P29274 1/20 0.64
ADORA1 P30542 1/20 0.64
HPGD P15428 4/20 0.61
HSD17B10 Q99714 3/20 0.61
KDM4E B2RXH2 2/20 0.61
F2 P00734 1/20 0.61
USP2 O75604 2/20 0.60
TP53 P04637 2/20 0.60
POLB P06746 7/20 0.60
MAPT P10636 4/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
LMNA P02545 1/20 0.60
PKM P14618 1/20 0.60
ALOX15 P16050 1/20 0.60
CTDSP1 Q9GZU7 1/20 0.57
TDP1 Q9NUW8 2/20 0.57
BACE1 P56817 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6205660 0.82 ADORA2A (0.68) ADORA2AADORA1KDM4EPOLBSMN1; SMN2
SCHEMBL19073153 0.82 ALDH1A1 (0.73) ALDH1A1ADORA2AADORA1HPGDHSD17B10
SCHEMBL7742074 0.79 NHERF1 (0.62) ADORA2AADORA1POLBSMN1; SMN2LMNA
SCHEMBL6204573 0.78 RAB9A (0.74) ALDH1A1HPGDHSD17B10TP53POLB
SCHEMBL20147105 0.78 CFTR (0.66) POLBLMNACFTR
SCHEMBL6204753 0.78 GABRP (0.67) ADORA2AADORA1POLBMAPTSMN1; SMN2
SCHEMBL6229836 0.78 CFTR (0.61) ADORA2AADORA1POLBSMN1; SMN2LMNA
SCHEMBL6818435 0.78 POLB (0.67) ADORA2AADORA1POLBSMN1; SMN2MEN1
SCHEMBL17338647 0.77 CFTR (0.66) LMNACFTR
Hydrochloric Acid SCHEMBL6204748 0.77 CFTR (0.60) ADORA2AADORA1POLBSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177177-B1 SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-02-23 EP claimed
US-6413956-B1 AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT NEUROGEN CORPORATION 2002-07-02 US claimed
EP-1177177-B1 SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-02-23 EP disclosed
US-6413956-B1 AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT NEUROGEN CORPORATION 2002-07-02 US disclosed