Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205901 | 0.79 | TRPA1 (0.46) | MAOAMAOB | |
| SCHEMBL6203597 | 0.78 | MAOA (0.40) | MAOAMAOBDPP4ALDH1A1HTT | |
| SCHEMBL6204382 | 0.76 | SLC1A1 (0.46) | MAOB | |
| SCHEMBL6204802 | 0.76 | MEN1 (0.40) | ALDH1A1HTTMAPTL3MBTL1LDHA | |
| SCHEMBL31694009 | 0.75 | DPP4 (0.44) | DPP4DPP7 | |
| SCHEMBL6203919 | 0.74 | PNMT (0.55) | — | |
| SCHEMBL9176216 | 0.74 | GABRA1 (0.48) | DPP4ALDH1A1HTTMAPT | |
| SCHEMBL2623873 | 0.74 | GABRA1 (0.48) | DPP4ALDH1A1HTTMAPT | |
| SCHEMBL16798238 | 0.74 | PTPRB (0.50) | MAOAMAOBDPP4ALDH1A1LDHA | |
| SCHEMBL15178216 | 0.74 | ALDH1A1 (0.37) | MAOAMAOBDPP4ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |