Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA1 | P56199 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205381 | 1.00 | ITGA1 (0.53) | ITGA1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6205383 | 1.00 | ITGA1 (0.53) | ITGA1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6204503 | 0.91 | HSD17B1 (0.52) | ITGA1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6205979 | 0.91 | HSD17B1 (0.52) | ITGA1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6205977 | 0.91 | HSD17B1 (0.52) | ITGA1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL6207012 | 0.88 | ITGA1 (0.69) | ITGA1WDR5NPC1PFKFB3MEN1 | |
| SCHEMBL6204782 | 0.88 | ITGA1 (0.69) | ITGA1WDR5NPC1PFKFB3MEN1 | |
| SCHEMBL6204438 | 0.88 | ITGA1 (0.57) | ITGA1WDR5NPC1MEN1KMT2A | |
| SCHEMBL6204447 | 0.88 | ITGA1 (0.57) | ITGA1WDR5NPC1MEN1KMT2A | |
| SCHEMBL6207007 | 0.88 | ITGA1 (0.69) | ITGA1WDR5NPC1PFKFB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100763-B1 | DIKETOACID-DERIVATIVES AS INHIBITORS OF POLYMERASES | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-06-22 | — | — | EP | claimed |