Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA1 | P56199 | 4/20 | 0.69 |
| ▸ | WDR5 | P61964 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207007 | 1.00 | ITGA1 (0.69) | ITGA1WDR5USP2HDAC1HDAC8 | |
| SCHEMBL6204782 | 1.00 | ITGA1 (0.69) | ITGA1WDR5USP2HDAC1HDAC8 | |
| SCHEMBL6204438 | 0.91 | ITGA1 (0.57) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6204444 | 0.91 | ITGA1 (0.57) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6204447 | 0.91 | ITGA1 (0.57) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6205381 | 0.88 | ITGA1 (0.53) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6205102 | 0.88 | ITGA1 (0.53) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6205383 | 0.88 | ITGA1 (0.53) | ITGA1WDR5USP2NPC1MEN1 | |
| SCHEMBL6206115 | 0.87 | ACLY (0.58) | ITGA1WDR5USP2HDAC1 | |
| SCHEMBL6206114 | 0.87 | ACLY (0.58) | ITGA1WDR5USP2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100763-B1 | DIKETOACID-DERIVATIVES AS INHIBITORS OF POLYMERASES | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-06-22 | — | — | EP | claimed |