Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204079 | 0.79 | PTGS1 (0.34) | NFE2L2PTGS1 | |
| SCHEMBL5410674 | 0.78 | TRPA1 (0.39) | NFE2L2TRPA1MEN1CYP1A2KMT2A | |
| SCHEMBL6204739 | 0.77 | NFE2L2 (0.49) | NFE2L2NQO2CYP1A2PTGS1 | |
| SCHEMBL7039143 | 0.75 | NFE2L2 (0.52) | NFE2L2NQO2TRPA1APPPTGS1 | |
| SCHEMBL27624827 | 0.74 | TRPA1 (0.41) | TRPA1MEN1MAPTCYP2C9CYP2C19 | |
| SCHEMBL6204192 | 0.73 | NFE2L2 (0.45) | NFE2L2MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL6204049 | 0.72 | NFE2L2 (0.41) | NFE2L2NQO2TRPA1MEN1LMNA | |
| SCHEMBL6204100 | 0.71 | CYP1A2 (0.40) | NFE2L2NQO2TRPA1MEN1LMNA | |
| SCHEMBL27681328 | 0.70 | NFE2L2 (0.47) | NFE2L2NQO2TRPA1MEN1LMNA | |
| SCHEMBL12772054 | 0.67 | CYP1A2 (0.46) | NFE2L2CYP1A2CYP2C19APPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |