Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563502 | 0.84 | NFE2L2 (0.47) | NFE2L2RELAPTGS1CYP1A2CYP3A4 | |
| SCHEMBL6204079 | 0.81 | PTGS1 (0.34) | NFE2L2RELAPTGS1PTGS2 | |
| SCHEMBL7039420 | 0.79 | NFE2L2 (0.58) | NFE2L2RELAPTGS1CYP1A2CYP3A4 | |
| SCHEMBL6203320 | 0.79 | RELA (0.47) | NFE2L2RELACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6203560 | 0.79 | ALDH1A1 (0.46) | PKMMAPK1MAOAMAOB | |
| SCHEMBL6204379 | 0.79 | CHRM5 (0.53) | NFE2L2RELACYP1A2CYP3A4CHRM5 | |
| SCHEMBL5244736 | 0.77 | NFE2L2 (0.52) | NFE2L2PTGS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6205425 | 0.77 | NFE2L2 (0.44) | NFE2L2PTGS1CYP1A2NQO2 | |
| SCHEMBL5410674 | 0.77 | TRPA1 (0.39) | NFE2L2RELACYP1A2MAOB | |
| SCHEMBL6202337 | 0.76 | TUBB4A (0.48) | CYP1A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |