Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204739 | 0.81 | NFE2L2 (0.49) | PTGS1PTGS2NFE2L2RELA | |
| SCHEMBL6205425 | 0.79 | NFE2L2 (0.44) | PTGS1NFE2L2 | |
| SCHEMBL16961847 | 0.75 | PTGS1 (0.40) | PTGS1PTGS2NFE2L2IDO1RELA | |
| SCHEMBL27624827 | 0.71 | TRPA1 (0.41) | — | |
| SCHEMBL5410674 | 0.70 | TRPA1 (0.39) | NFE2L2IDO1RELA | |
| SCHEMBL8140047 | 0.67 | SOD1 (0.40) | IDO1 | |
| SCHEMBL6203320 | 0.66 | RELA (0.47) | NFE2L2IDO1RELA | |
| SCHEMBL6203560 | 0.66 | ALDH1A1 (0.46) | IDO1 | |
| Methoxymethane SCHEMBL27837378 | 0.65 | CA12 (0.47) | PTGS1PTGS2NFE2L2IDO1 | |
| SCHEMBL7563502 | 0.64 | NFE2L2 (0.47) | PTGS1PTGS2NFE2L2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |