Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27681328 | 0.84 | NFE2L2 (0.47) | NFE2L2NQO2TRPA1MAPTMEN1 | |
| SCHEMBL2153833 | 0.72 | NFE2L2 (0.44) | NFE2L2NQO2TRPA1MAPTMEN1 | |
| SCHEMBL6205425 | 0.72 | NFE2L2 (0.44) | NFE2L2NQO2TRPA1MAPTMEN1 | |
| SCHEMBL654529 | 0.69 | NFE2L2 (0.48) | NFE2L2NQO2TRPA1MAPTMEN1 | |
| SCHEMBL6204838 | 0.68 | ALDH1A1 (0.47) | MAPTNPSR1ALDH1A1POLB | |
| SCHEMBL6204213 | 0.68 | RELA (0.45) | NFE2L2MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL6205403 | 0.68 | CHRM5 (0.50) | NFE2L2NQO2CYP1A2 | |
| SCHEMBL31246192 | 0.67 | TAAR1 (0.44) | MAPTMEN1KMT2AL3MBTL1PTGS1 | |
| SCHEMBL1386307 | 0.65 | NFE2L2 (0.44) | NFE2L2ALDH1A1L3MBTL1APPPTGS1 | |
| SCHEMBL653095 | 0.64 | NFE2L2 (0.43) | NFE2L2TRPA1MAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |