Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205602 | 0.87 | PARP1 (0.37) | PARP1PDE4DHTTSMN1; SMN2PDE4A | |
| SCHEMBL6205328 | 0.84 | PARP1 (0.36) | PARP1STAT3PDE4DHTTSMN1; SMN2 | |
| SCHEMBL6202760 | 0.84 | CDK1 (0.40) | PDE4DSMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL3445270 | 0.78 | CDK1 (0.46) | STAT3SMN1; SMN2LMNAAURKA | |
| SCHEMBL6203171 | 0.77 | CCNE1 (0.37) | AURKA | |
| SCHEMBL3445690 | 0.77 | STAT3 (0.41) | PARP1STAT3HTTSMN1; SMN2MAPT | |
| SCHEMBL3446443 | 0.76 | CDK1 (0.45) | PARP1STAT3HTTSMN1; SMN2MAPT | |
| SCHEMBL3445494 | 0.76 | STAT3 (0.40) | PARP1STAT3HTTSMN1; SMN2ACHE | |
| SCHEMBL6203495 | 0.75 | PRUNE1 (0.35) | PDE4DPDE5APDE6CPRUNE1 | |
| SCHEMBL3444313 | 0.74 | CDK1 (0.52) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |