Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207031 | 0.79 | CES2 (0.47) | MAPTALDH1A1GAALMNANPC1 | |
| SCHEMBL6207827 | 0.77 | HPGD (0.52) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL514996 | 0.76 | MAPT (0.46) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL6205116 | 0.76 | NPC1 (0.50) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL6206781 | 0.76 | RAB9A (0.50) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL4067136 | 0.75 | MAPT (0.41) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL262368 | 0.74 | NPC1 (0.58) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL27976004 | 0.73 | MAPT (0.43) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL6208809 | 0.73 | HPGD (0.51) | MAPTALDH1A1GAASMN1; SMN2TSHR | |
| SCHEMBL28884212 | 0.73 | MAPT (0.44) | MAPTALDH1A1KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |