Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28953526 | 0.85 | HPGD (0.49) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL717176 | 0.83 | HPGD (0.57) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL446339 | 0.82 | HPGD (0.59) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6205116 | 0.80 | NPC1 (0.50) | HPGDALDH1A1RAB9ASMN1; SMN2ESR1 | |
| SCHEMBL125031 | 0.79 | HPGD (0.56) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6207827 | 0.78 | HPGD (0.52) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7172322 | 0.78 | HPGD (0.54) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL554492 | 0.78 | HPGD (0.54) | HPGDALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL11267813 | 0.77 | NPC1 (0.54) | HPGDALDH1A1RAB9ACTSDESR1 | |
| SCHEMBL6207031 | 0.77 | CES2 (0.47) | HPGDALDH1A1RAB9AL3MBTL1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |