Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207249 | 0.87 | TSHR (0.49) | RAB9ASMN1; SMN2NPC1HPGDPKM | |
| SCHEMBL2153551 | 0.81 | CES2 (0.62) | RAB9ASMN1; SMN2NPC1HPGDPKM | |
| SCHEMBL6207827 | 0.81 | HPGD (0.52) | RAB9ASMN1; SMN2NPC1HPGDL3MBTL1 | |
| SCHEMBL8925810 | 0.80 | CES2 (0.52) | RAB9ASMN1; SMN2NPC1HPGDPKM | |
| SCHEMBL6205116 | 0.79 | NPC1 (0.50) | RAB9ASMN1; SMN2NPC1HPGDPKM | |
| SCHEMBL6207031 | 0.79 | CES2 (0.47) | RAB9ANPC1HPGDPKML3MBTL1 | |
| SCHEMBL6208809 | 0.77 | HPGD (0.51) | RAB9ASMN1; SMN2NPC1HPGDL3MBTL1 | |
| SCHEMBL6205639 | 0.76 | MAPT (0.43) | RAB9ASMN1; SMN2NPC1L3MBTL1GAA | |
| SCHEMBL6206850 | 0.76 | LMNA (0.46) | RAB9ANPC1L3MBTL1GAALMNA | |
| SCHEMBL6206789 | 0.74 | CTSD (0.50) | RAB9ASMN1; SMN2NPC1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |